The game started out as Spider-Man swings into a burning building. He beat bombers building and rescued a woman from being murdered. Then jump to the next day. Former best friend Harry Osborn does not talk to him anymore and he has a new rival at the Daily Bugle: Eddie Brock. Meanwhile, escaped convict Flint
Marko falls into a lab pit and turns into sand. A small meteor crashes, with a symbiote inside.
Spider-Man takes Mary Jane Watson, his girlfriend, on a thrill ride, and after that, talks about Harry. Mary Jane entertain her, while talking, the symbiote attaches to Peter's shoe. Meanwhile, Harry came out of the space in the Green Goblin lair, filled with Goblin gas.
After visiting science teacher Dr. Connors, who turned into a Lizard by experimenting on himself to grow a new arm. Lizard then turns into someone else lizards, then escapes into the sewers, Spider-Man then follows and defeats the Lizard Lizard but passed over in the ditch. Harry (now the New Goblin) attacks Peter. They went on a high-flying battle in New Goblin glider, but Goblin is defeated and knocked unconscious. Peter brings New Goblin to the hospital, where he will be treated.
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